Bacterial microcompartment shells of diverse functional types possess pentameric vertex proteins

Diverse bacterial microcompartment organelles.

Bacterial microcompartments (MCPs) are sophisticated protein-based organelles used to optimize metabolic pathways. They consist of metabolic enzymes encapsulated within a protein shell, which creates an ideal environment for catalysis and facilitates the channeling of toxic/volatile intermediates to downstream enzymes. The metabolic processes that require MCPs are diverse and widely distributed...

Kainate binding proteins possess functional ion channel domains.

Kainate binding proteins (KBPs) are highly homologous to ionotropic glutamate receptors; however, no ion channel function has been demonstrated for these proteins. To investigate possible reasons for the apparent lack of ion channel function we transplanted the ion channel domains of five KBPs into glutamate receptors GluR 6 and GluR1. In each case we obtained functional chimeric receptors in w...

Polytypi values possess polykinded types

Polytypic Values Possess Polykinded Types

Polytypic Values Possess Polykinded Types

A polytypic value is one that is defined by induction on the structure of types. In Haskell types are assigned so-called kinds that distinguish between manifest types like the type of integers and functions on types like the list type constructor. Previous approaches to polytypic programming were restricted in that they only allowed to parameterize values by types of one fixed kind. In this pap...